TABLE 3.
Cross-neutralizing activity against heterologous virus, determined by using plasma from antiretroviral-untreated subjectsa
| Source of virus | Neutralizing antibody titer from plasma fromb:
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Virologic controller patient
|
Virologic noncontroller patient
|
||||||||||
| 1504 | 1508 | 1516c | 1002 | 1006 | 1008 | 1017 | 1048 | 1512 | 1515 | 3018 | |
| Patient groups and ID no. | |||||||||||
| Controllers | |||||||||||
| 1504 | 72 | 82 | 45 | 196* | 375* | 264* | 117* | 212* | 397* | 57 | 101 |
| 1508 | 88* | 83 | 83* | 118* | 130* | 118* | 107* | 105* | 498* | 33 | 103 |
| Noncontrollers | |||||||||||
| 1002 | 51 | 67 | 37 | 94* | 118* | 37 | 51 | 80* | 211* | 46 | |
| 1006 | 57 | 99 | 71* | 158* | 57 | 177* | 100* | 143* | 251* | 30 | 50 |
| 1008 | 123* | 100 | 64* | 117* | 395* | 52 | 68* | 114* | 192* | 33 | 92 |
| 1017 | 244* | 175* | 64* | 388* | 137* | 175* | 105* | 1,119* | 175* | 425* | 114 |
| 1048 | 93* | 92 | 35 | 131* | 350* | 64* | 95* | 102* | 573* | 50 | 86 |
| 1512 | 57 | 56 | 32 | 114* | 49 | 55 | 42 | 97* | 140 | 33 | 77 |
| 1515 | 91* | 249* | 69* | 367* | 122* | 89* | 57 | 310* | 615* | 41 | 139 |
| 3018 | 103* | 140 | 81* | 249* | 266* | 187* | 153* | 198* | 1,272* | 77* | 107 |
| PCAT | |||||||||||
| 2004 | 39 | 89 | 47 | 56 | 47 | 48 | 48 | 79* | 1,195* | 37 | 81 |
| 3002 | 61 | 82 | 58 | 98* | 165* | 75* | 40 | 152* | 245* | 38 | 78 |
| 3037 | 129* | 156 | 95* | 418* | 820* | 154* | 176* | 373* | 864* | 118* | 81 |
| 3039 | 56 | 54 | 26 | 229* | 153* | 55 | 41 | 83* | 144 | 43 | 95 |
| Virus and lab strains | |||||||||||
| JR-CSF | 102 | 116 | 75 | 390 | 546 | 182 | 117 | 613 | 314 | 42 | 108 |
| NL4-3 | 4,713 | 1,720 | 906 | 1,891 | 2,058 | 639 | 3,702 | 5,043 | 1,950 | 1,366 | 781 |
| aMLV | 24 | 58 | 20 | 31 | 26 | 20 | 20 | 22 | 50 | 20 | 65 |
Neutralizing HIV antibody titers were measured in plasma derived from chronically infected, antiretroviral drug-untreated subjects meeting our study definition of virologic controllers or noncontrollers (patient identification [ID] numbers are given). Neutralization titers were measured against a panel of heterologous primary viruses representing all three subject groups (virologic controllers, virologic noncontrollers, and PCAT).
See footnote b of Table 2 for explanations of neutralizing antibody titer, asterisks, and boldface type.
Virus could not be amplified for subject 1516.