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. 2006 Jun 2;2(6):e54. doi: 10.1371/journal.pcbi.0020054

Figure 3. The Nomenclature Definitions That We Used to Classify the Various Outcomes of the Phylogenetic Relationships between the Chicken and Human GPCRs.

Figure 3

(A) Orthologs. The chicken sequence will inherit the human sequence name with “gg” (G. gallus) as prefix (according to the guidelines of CHICKBASE hosted at the Roslin Institute).

(B) One orthologous pair in receptor family X together with a missing human ortholog. The chicken sequence will inherit the receptor family name “X” together with the appendix “n1” (novel 1); for example, see Figure 5A ggGPR119n1.

(C) Gene duplication in the chicken genome/gene loss in the human genome. The chicken sequences will inherit the human sequence name. The two chicken sequences will be discriminated by “a, b” appendix; for example, see Figure 5A ggADORA2Ba and ggADORA2Bb.

(D) Gene expansion in the chicken genome/gene loss in the human genome (n > 2). The chicken sequences will inherit the name of the closest human sequence. The chicken sequences will be discriminated by appendix “a, b, c …”; for example, see Figure 5D ggGPR43n1a–1h.

(E) Gene duplication in the human genome/gene loss in the chicken genome. The chicken sequence will inherit a combination of the two human sequence names; for example, see Figure 4A ggGPR111/115.

(F) Gene expansion in the human genome/gene loss in the chicken genome (n > 2). The chicken gene will be given a novel name associated with the closest human receptor family; for example, see Figure 5D ggMRGn1.