Figure 4.

Change from baseline in the effective arterial elastance (ESP/SV_index) and ventriculo-vascular coupling (ESD/SV_index). Baseline derived echocardiographic data did not differ statistically in the four animals with two predrug assessments (Bland–Altman Test). Values are depicted as percent control value ± SE. Exposure to ALT-711 was associated with a significant reduction in ESP/SV_index (P = 0.02) and ESD/SV_index (P = 0.002). *, significantly differs from baseline by Bonferroni/Dunn test.