Table 2.
Five-Year Rates of Advanced AMD,* by Drusen Area and Maximum Drusen Size at Baseline
|
Maximum Drusen Size, No. (%) |
||||||||
|---|---|---|---|---|---|---|---|---|
| Drusen Area | None | Questionable | Small: <C-0 (<63 μm) | Intermediate: ≥C-0, <C-1 (63–124 μm) | Large: ≥C-1, <C-2 (125–249 μm) | Very Large: ≥C-2 (≥250 μm) | Total | PValue, Trend Test |
| None, questionable, <C-0 | ||||||||
| At risk | 155 | 91 | 633 | 879 | ||||
| NeoAMD | 0 | 1 | 0 | 1 | ||||
| CGA | 0 | 0 | 1 | 1 | ||||
| Total† | 0 | 1(1.1) | 1 (0.2) | 2 (0.2) | .94 | |||
| ≥C-0. <C-1 | ||||||||
| At risk | 463 | 180 | 643 | |||||
| NeoAMD | 1 | 5 | 6 | |||||
| CGA | 0 | 0 | 0 | |||||
| Total† | 1 (0.2) | 6 (3.3) | 7 (1.1) | .001 | ||||
| ≥C-1,<C-2 | ||||||||
| At risk | 133 | 256 | 74 | 463 | ||||
| NeoAMD | 1 | 5 | 1 | 7 | ||||
| CGA | 1 | 0 | 1 | 2 | ||||
| Total† | 2 (1.5) | 7 (2.7) | 2 (2.7) | 11 (2.4) | .52 | |||
| ≥C-2, <I-2 | ||||||||
| At risk | 13 | 144 | 155 | 3 | 315 | |||
| NeoAMD | 1 | 3 | 7 | 0 | 11 | |||
| CGA | 0 | 1 | 1 | 0 | 2 | |||
| Total† | 1 (7.7) | 4 (2.8) | 8 (5.2) | 0 | 13 (4.1) | .67 | ||
| ≥I-2, <O-2 | ||||||||
| At risk | 5 | 86 | 140 | 28 | 259 | |||
| NeoAMD | 0 | 2 | 9 | 1 | 12 | |||
| CGA | 0 | 1 | 3 | 0 | 4 | |||
| Total† | 0 | 4 (4.7) | 14 (10.0) | 1 (3.6) | 19 (7.3) | .48 | ||
| ≥O-2, <0.5 DA | ||||||||
| At risk | 2 | 28 | 95 | 61 | 186 | |||
| NeoAMD | 0 | 1 | 7 | 8 | 16 | |||
| CGA | 0 | 1 | 3 | 4 | 8 | |||
| Total† | 0 | 2 (7.1) | 10 (10.5) | 14 (23.0) | 26 (14.0) | .01 | ||
| ≥0.5 DA, <1.0 DA | ||||||||
| At risk | 0 | 11 | 68 | 85 | 164 | |||
| NeoAMD | 1 | 8 | 11 | 20 | ||||
| CGA | 2 | 5 | 14 | 21 | ||||
| Total† | 3 (27.3) | 14 (20.6) | 25 (29.4) | 42 (25.6) | .37 | |||
| ≥1.0 DA | ||||||||
| At risk | 0 | 8 | 71 | 224 | 303 | |||
| NeoAMD | 1 | 7 | 31 | 39 | ||||
| CGA | 0 | 10 | 26 | 36 | ||||
| Total† | 1 (12.5) | 17 (23.9) | 62 (27.7) | 80 (26.4) | .30 | |||
| Total | ||||||||
| At risk | 155 | 91 | 1249 | 713 | 603 | 401 | 3212 | |
| NeoAMD | 0 | 1 | 3 | 18 | 39 | 51 | 112 | |
| CGA | 0 | 0 | 2 | 5 | 23 | 44 | 74 | |
| Total† | 0 | 1 (1.1) | 5 (0.4) | 27 (3.8) | 65 (10.8) | 102 (25.4) | 200 (6.2) | |
| P value, trend test | NA | NA | .02 | .01 | <.001 | .01 | NA | NA |
Abbreviations: AMD, age-related macular degeneration; CGA, geographic atrophy involving center of macula; DA, disc area; NA, not applicable; NeoAMD, neovascular AMD.
*
In the right eyes of 3212 participants free of advanced AMD in both eyes at baseline. Cells that cannot, by definition, have entries are blank.
†
Numbers given for NeoAMD and CGA represent eyes with this outcome only; where the total exceeds the sum of NeoAMD + CGA, the difference represents eyes that were graded as both NeoAMD and CGA, usually at different visits.