Table 4.
Five-Year Rate of Advanced AMD,* by Area of Increased Pigmentation and by Area of Depigmentation–Presence of Geographic Atrophy at Baseline
|
Depigmentation, No. (%) |
||||||||
|---|---|---|---|---|---|---|---|---|
| Increased Pigment | None | Questionable | <I-2 | ≥I-2, <O-2 | ≥O-2, <0.5 DA | ≥0.5 DA | GA, No. (%) | Total |
| None | ||||||||
| At risk | 2412 | 24 | 5 | 8 | 1 | 6 | 8 | 2464 |
| NeoAMD | 38 | 1 | 0 | 0 | 0 | 1 | 1 | 41 |
| CGA | 0 | 1 | 0 | 0 | 0 | 1 | 3 | 5 |
| Total† | 38 (1.6) | 2 (8.3) | 0 | 0 | 0 | 3 (50.0) | 5 (62.5) | 48 (1.9) |
| Questionable | ||||||||
| At risk | 52 | 5 | 2 | 5 | 1 | 0 | 1 | 66 |
| NeoAMD | 7 | 0 | 0 | 0 | 0 | 0 | 7 | |
| CGA | 1 | 0 | 0 | 0 | 0 | 1 | 2 | |
| Total† | 9 (17.3) | 0 | 0 | 0 | 0 | 1 (100.0) | 10 (15.2) | |
| <C-0 | ||||||||
| At risk | 46 | 6 | 0 | 3 | 2 | 2 | 0 | 59 |
| NeoAMD | 2 | 0 | 0 | 0 | 0 | 2 | ||
| CGA | 2 | 0 | 1 | 0 | 1 | 4 | ||
| Total† | 4 (8.7) | 0 | 1 (33.3) | 0 | 2 (100.0) | 7 (11.9) | ||
| ≥C-0, <C-1 | ||||||||
| At risk | 101 | 19 | 21 | 12 | 3 | 2 | 8 | 166 |
| NeoAMD | 12 | 0 | 0 | 1 | 0 | 0 | 0 | 13 |
| CGA | 3 | 1 | 0 | 0 | 1 | 0 | 3 | 8 |
| Total† | 16 (15.8) | 1 (5.3) | 0 | 1 (8.3) | 1 (33.3) | 1 (50.0) | 3 (37.5) | 23 (13.9) |
| ≥C-1, <C-2 | ||||||||
| At risk | 114 | 39 | 36 | 34 | 18 | 9 | 9 | 259 |
| NeoAMD | 6 | 3 | 4 | 5 | 5 | 3 | 0 | 26 |
| CGA | 10 | 1 | 4 | 2 | 1 | 1 | 4 | 23 |
| Total† | 16 (14.0) | 4 (10.3) | 8 (22.2) | 7 (20.6) | 6 (33.3) | 4 (44.4) | 4 (44.4) | 49 (18.9) |
| ≥C-2, <O-2 | ||||||||
| At risk | 65 | 23 | 23 | 29 | 12 | 23 | 8 | 183 |
| NeoAMD | 7 | 0 | 1 | 3 | 2 | 5 | 1 | 19 |
| CGA | 11 | 1 | 2 | 7 | 2 | 3 | 2 | 28 |
| Total† | 21 (32.3) | 2 (8.7) | 3 (13.0) | 10 (34.5) | 4 (33.3) | 10 (43.5) | 3 (37.5) | 53 (29.0) |
| ≥ O-2 | ||||||||
| At risk | 3 | 1 | 1 | 1 | 2 | 6 | 1 | 15 |
| NeoAMD | 1 | 0 | 0 | 1 | 0 | 2 | 0 | 4 |
| CGA | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 4 |
| Total† | 1 (33.3) | 1 (100.0) | 0 | 1 (100.0) | 1 (50.0) | 5 (83.3) | 1 (100.0) | 10 (66.7) |
| Total | ||||||||
| At risk | 2793 | 117 | 88 | 92 | 39 | 48 | 35 | 3212 |
| NeoAMD | 73 | 4 | 5 | 10 | 7 | 11 | 2 | 112 |
| CGA | 27 | 5 | 6 | 10 | 5 | 7 | 14 | 74 |
| Total† | 105 (3.8) | 10 (8.5) | 11 (12.5) | 20 (21.7) | 12 (30.8) | 25 (52.1) | 17 (48.6) | 200 (6.2) |
Abbreviations: AMD, age-related macular degeneration; CGA, geographic atrophy involving center of macula; DA, disc area; GA, geographic atrophy; NeoAMD, neovascular AMD.
*
In the right eyes of 3212 participants free of advanced AMD in both eyes at baseline.
†
Numbers given for NeoAMD and CGA represent eyes with this outcome only; where the total exceeds the sum of NeoAMD + CGA, the difference represents eyes that were graded as both NeoAMD and CGA, usually at different visits.