Table 5.

Five-Year Rates of Advanced AMD,^* by Severity of Pigmentary Abnormalities at Baseline

			No. (%)
Step	Pigmentary Abnormalities	No. at Risk	NeoAMD	CGA	Both	Total
1	None	2412	38 (1.6)	0	0	38 (1.6)
2	Increased pigment ≥questionable and/or depigmentation <I-2	586	44 (7.5)	38 (6.5)	6 (1.0)	88 (15.0)
3	Depigmentation ≥I-2, <0.5 DA	131	17 (13.0)	15 (11.5)	0	32 (24.4)
4	Depigmentation ≥0.5 DA	48	11 (22.9)	7 (14.6)	7 (14.6)	25 (52.1)
5	Noncentral GA ≥questionable	35	2 (5.2)	14 (40.0)	1 (2.9)	17 (48.6)
	Total	3212	112 (3.5)	74 (2.3)	14 (0.4)	200 (6.2)

Abbreviations: AMD, age-related macular degeneration; CGA, geographic atrophy involving center of macula; DA, disc area; GA, geographic atrophy; NeoAMD, neovascular AMD.

^*In the right eyes of 3212 participants free of advanced AMD in both eyes at baseline.