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. 2006 May 15;20(10):1331–1342. doi: 10.1101/gad.1413306

Figure 1.

Figure 1.

Ras overexpression and mutation, and reduction/loss of TGFβRII expression in human HNSCC samples examined by qRT–PCR. Each pair of bars in the main graph represents the fold change of tumor and adjacent mucosa from a single case relative to a normal control group. The case ID and numbers were identical and in the same order in all three panels. The average fold change for each tissue type is shown in the inset. Seven normal oropharyngeal samples from sleep apnea patients and 32 pairs of HNSCC and adjacent tissue samples were examined. The dotted horizontal line in each of the main graphs represents the average expression level of each molecule from the normal control group. (A) Expression levels of K-ras. The average K-ras mRNA levels in HNSCC samples and adjacent tissue samples are presented in the inset. (†) Tumors with a G-to-D mutation at codon 12 of the K-ras gene. (B) Expression levels of H-ras. The average H-ras mRNA levels in HNSCCs and adjacent tissue samples are presented in the inset. (C) TGFβRII mRNA levels in human HNSCC samples. The average levels of TGFβRII mRNA in HNSCC and adjacent tissue samples are presented in the inset. (*) p < 0.01 in comparison with normal control.