Skip to main content
. 2006 May 15;20(10):1353–1364. doi: 10.1101/gad.1387406

Figure 6.

Figure 6.

Genetic interaction between K17 and TNFα pathway. (A, left) Rescue of hair loss in K17−/− TNFα−/− mice. A K17−/− littermate is shown at right for reference. (B,B′) Hematoxylin/eosin-stained skin tissue sections from K17−/− TNFα+/+ (B) and K17−/− TNFα−/− (B′) mice at P14. Arrows point to hair bulbs. Bars, 50 μm. (C,C′) TUNEL (green) and Hoechst (blue) dual stainings in backskin sections prepared from K17−/− TNFα+/+ (C) and K17−/− TNFα−/− (C′) mice at P14. Arrows point to TUNEL positive staining. Bars, 50 μm. (D,D′) In situ hybridization for FGF5 mRNA in K17−/− TNFα+/+ (D) and K17−/− TNFα−/− (D′) backskin at P7. Four percent paraformaldehyde-fixed frozen sections were hybridized with antisense (D,D′) or sense (not shown) probes. Bars, 50 μm. (Bulb) Hair bulb; (epi) epidermis; (mat) matrix; (ORS) outer root sheath. Asterisks denote melanin pigments in hair bulb.