FIgure 4.

Charles B. Huggins, working in the 1930s and early 1940s at the Ben May Laboratory at the University of Chicago, was the first to apply scientific method to a study of the relationship of prostate growth and testosterone. He observed that men with advanced prostate cancer could be markedly relieved by castration or estrogen therapy. He also noted that the glandular epithelium underwent marked involution in men with benign prostatic hyperplasia who were similarly treated. For his work, he received the Nobel Prize in Physiology and Medicine in 1966.