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The conversion of testosterone to dihydrotestosterone is catalyzed by the enzyme 5α-reductase (5AR), which exists in 2 forms: Type 1 and Type 2, both of which are found in the prostate. Type 1 is produced primarily in liver and skin and is carried to the prostate via the systemic circulation. Type 2 is the major form in the prostate. Finasteride inhibits Type 2 5AR. Dutasteride inhibits both Type 1 and 2 5AR (dual inhibitor). DHT, dihydrotestosterone.
