Figure 7.

Distribution of messenger RNA (mRNA) for Type 2 (left) and Type 1 (right) 5α-reductase (5AR) in human prostate tissues: normal, BPH, and CaP. In BPH tissue, both types of 5AR are over-expressed; in CaP tissue, only Type 1 is over-expressed. Note difference in vertical axis scale. BPH, benign prostatic hyperplasia; CaP, cancer of the prostate; TBP, TATA-binding protein; PZ, peripheral zone; TZ, transition zone; CZ, central zone. Reprinted from Iehle C et al.²⁴ with permission from Elsevier.