Figure 9.

Differences in testosterone-dependent (Wolffian duct) and DHT-dependent (urogenital sinus) structures in embryogenesis of male genitalia. The “guevedoces” are congenitally deficient in DHT, resulting in failure of the urogenital sinus derivatives to differentiate properly. At puberty, the outpouring of testosterone causes these biologic males to experience descent of testes, phallic enlargement, and development of a male body habitus. DHT, dihydrotestosterone. Reprinted from Bartsch G et al.¹² with permission from Springer-Verlag.