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. 2004;6(Suppl 10):S3–S12.

Table 2.

Use of Bone-Targeted Radionuclides for Treatment of Metastatic Bone Pain: Indications and Contraindications

Indications

  • Bone scan positive

    • Osteoblastic lesions

  • Bone pain due to cancer

  • Multifocal disease

Relative Contraindications

  • Predominant soft-tissue pain

  • Unifocal bone lesions

  • “Osteolytic” lesions

    • Poor uptake on bone scan

Absolute Contraindications

  • Severe marrow suppression

  • Severe renal dysfunction