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Dicoumarol-induced p53 degradation is inhibited by overexpression of NQO1. Parental HCT116 cells (−) and a pool of HCT116 stable clones overexpressing HA-tagged NQO1 were incubated without (−) or with 200 and 400 μM dicoumarol for 4 h. Immunoblot analysis was carried out with Pab 1801 monoclonal anti-p53 antibody, and the blots were then stripped and reprobed with monoclonal anti-HA antibody as a control for NQO1 expression.
