TABLE 3A.
Plasma acid-base parameters of Control animals in response to bosentan
| pH | PCO2 (mm Hg) | Calculated [HCO3] (mM) | Measured [TCO2] (mM) | |
|---|---|---|---|---|
| 20% Protein (Control) Week 1 (n = 8) | 7.41 ± 0.02 | 39.2 ± 1.0 | 24.1 ± 0.9 | 25.2 ± 0.6 |
| 20% Protein (+Bosentan) Week 1 (n = 8) | 7.40 ± 0.02 | 38.9 ± 0.9 | 23.7 ± 0.6 | 24.8 ± 0.6 |
| 20% Protein (+Bosentan) Week 3 (n = 8) | 7.39 ± 0.02 | 39.8 ± 1.0 | 23.6 ± 0.7 | 24.5 ± 0.5 |
| 20% Protein (+Bosentan) Week 3 (n = 8) | 7.40 ± 0.02 | 38.2 ± 0.9 | 23.1 ± 0.6 | 24.1 ± 0.5 |
Values are means ± SE. * p < 0.05 vs. 20% protein; n = number of animals.