Table 3.
Mean score in each domain of ADAS-cog score throughout the study (intent-to-treat population analysis)
| Mean ± SD | ||||
|---|---|---|---|---|
| ADAS-cog domain | Baseline | Week 8 | Week 12 | Week 24 |
| Word-recall task | 6.4 ± 0.2 | 6.0 ± 0.2* | 5.4 ± 0.3* | 5.5 ± 0.2* |
| Naming | 0.3 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 |
| Commands | 1.4 ± 0.1 | 1.4 ± 0.2 | 1.1 ± 0.1 | 1.2 ± 0.1 |
| Constructional | 1.2 ± 0.1 | 1.1 ± 0.1 | 1.1 ± 0.1 | 1.2 ± 0.1 |
| Ideational | 0.8 ± 0.1 | 0.9 ± 0.1 | 0.8 ± 0.1 | 0.7 ± 0.1 |
| Orientation | 3.1 ± 0.3 | 3.2 ± 0.3 | 3.2 ± 0.8 | 3.2 ± 0.3 |
| Word recognition task | 5.4 ± 0.5 | 4.6 ± 0.4 | 4.3 ± 0.5* | 4.3 ± 0.5* |
| Remembering | 1.7 ± 0.2 | 1.4 ± 0.2* | 1.2 ± 0.2* | 1.3 ± 0.2* |
| Spoken language ability | 0.4 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 |
| Comprehension | 0.6 ± 0.1 | 0.3 ± 0.1* | 0.4 ± 0.1* | 0.4 ± 0.1* |
| Word-finding difficulty | 0.5 ± 0.1 | 0.4 ± 0.1 | 0.3 ± 0.1 | 0.2 ± 0.1 |
ADAS-cog, Alzheimer's Disease Assessment Scale-cognitive subscale
*
p < 0.05 vs. baseline.