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. Author manuscript; available in PMC: 2006 Jun 2.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2004 Mar 18;24(5):955–961. doi: 10.1161/01.ATV.0000126372.14332.70

Figure 1.

Figure 1

A, Serum P levels before treatment with placebo and P cream were 168 ± 64 pg/mL in placebo-treated monkeys (n=5) and 60 ± 17 pg/mL in P cream-treated monkeys (n=7), respectively. After 4 weeks of P cream treatment, rhesus (n=7) showed a significant 10× increase in P levels to 614 ± 126 pg/mL, whereas the P levels in placebo-treated rhesus (n=5) did not change significantly (248 ± 126 pg/mL). *Significance compared with baseline P. There was a significant difference between placebo and P groups after treatment at P<0.05. B, Urinary pregnanediol levels in P-treated and placebo cream-treated monkeys. Urine obtained after 28-day application of P or placebo cream was analyzed for pregnanediol and creatinine levels. The creatinine levels were comparable in both groups (P-treated=6.49 ± 1.13 mg/dL and placebo-treated=6.52 ± 2.82 mg/dL). The pregnanediol levels were 64.21 ± 23.31 ng/mg creatinine in the P-treated group and 1.82 ± 1.8 ng/mg creatinine in the placebo group. There was a significant difference between placebo and P groups after treatment at P<0.05.