Figure 3.

Susceptibility of FMS₇–IFN-α2 toward enzymatic degradation by α-chymotrypsin. FMS₇–IFN-α2 and native IFN-α2 (1 mg/ml each in PBS buffer, pH 7.4) were incubated with α-chymotrypsin (1% wt/wt). At the indicated time points, aliquots were subjected to analytical HPLC. The quantity of the cytokine (peak area) at t = 0 was assigned 100%.