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Intravenously administered FMS7–IFN-α in mice facilitates prolonged circulating antiviral activity. Groups of mice (n = 5 for each group) received intravenously (10 μg/mouse) native-IFN-α2 (A) or FMS7–IFN-α2 (B and C). Blood aliquots were withdrawn at the indicated time points. Circulatory antiviral activities in aliquots were determined in human WISH cells before (B) and after (C) an additional period of incubation for 18 h (pH 8.5, 37°C).
