Table 1.
Homology of CaIHV-3, EBV, and KSHV ORFs
| CaIHV-3 name | CaIHV-3 vs.
|
Description | |||
|---|---|---|---|---|---|
| EBV
|
KSHV
|
||||
| Name | % Hom | Name | % Hom | ||
| C1 | LMP1 | 18.8 | Transforming gene | ||
| K1 | Transforming gene | ||||
| BARF1 | CSF1R homologue | ||||
| ORF4 | Complement binding | ||||
| ORF1 | BALF1 | 27.6 | bcl-2 homologue | ||
| ORF2 | BALF2 | 68.3 | ORF6 | 40.3 | DNA binding protein |
| ORF3 | BALF3 | 55.2 | ORF7 | 34.8 | |
| ORF4 | BALF4 | 58.7 | ORF8 | 34.9 | Glycoprotein B |
| ORF5 | BALF5 | 73.5 | ORF9 | 48.6 | DNA polymerase |
| ORF6 | BILF1 | 38.2 | Membrane protein | ||
| ORF7 | Raji LF1 | 24.1 | |||
| ORF10 | |||||
| ORF8 | Raji LF2 | 63.6 | ORF11 | 22.4 | |
| Raji LF3 | |||||
| BILF2 | Glycoprotein (gp55) | ||||
| C2 | Membrane protein | ||||
| K2 | IL-6 homologue | ||||
| ORF02 | Dihydrofolate reductase | ||||
| K3 | IE-1 homologue | ||||
| ORF70 | Thymidylate synth. | ||||
| K4 | vMIP-II | ||||
| K5 | IE-1 homologue | ||||
| K6 | vMIP-I | ||||
| K7 | |||||
| ORF16 | bcl-2 homologue | ||||
| ORF9 | BVRF2 | 38.3 | ORF17 | 28.4 | Capsid protein |
| ORF10 | BVLF1.5 | 36.2 | ORF18 | 29.8 | |
| ORF11 | BVRF1 | 47.4 | ORF19 | 33.5 | Tegument protein |
| ORF12 | BXRF1 | 37.1 | ORF20 | 25.2 | |
| ORF13 | BXLF1 | 47.0 | ORF21 | 24.8 | Thymidine kinase |
| ORF14 | BXLF2 | 44.6 | ORF22 | 20.9 | Glycoprotein H |
| ORF15 | BTRF1 | 57.0 | ORF23 | 24.8 | |
| ORF16 | BcRF1 | 36.5 | ORF24 | 27.8 | |
| ORF17 | BcLF1 | 75.5 | ORF25 | 55.7 | Capsid protein |
| ORF18 | BDLF1 | 70.1 | ORF26 | 50.0 | Capsid protein |
| ORF19 | BDLF2 | 26.3 | ORF27 | 13.1 | |
| BDLF3 | Glycoprotein (gp 150) | ||||
| ORF28 | |||||
| ORF20 | BDRF1 | 74.6 | ORF29b | 57.8 | Packaging protein |
| ORF21 | BDLF4 | 51.9 | ORF31 | 28.3 | |
| ORF22 | BGLF1 | 30.6 | ORF32 | 15.0 | |
| ORF23 | BGLF2 | 57.4 | ORF33 | 24.5 | |
| ORF24 | BGRF1 | 63.7 | ORF29a | 45.3 | Packaging protein |
| ORF25 | BGLF3 | 48.2 | ORF34 | 30.0 | |
| ORF26 | BGLF3.5 | 35.6 | ORF35 | 26.2 | |
| ORF27 | BGLF4 | 59.9 | ORF36 | 24.1 | Kinase |
| ORF28 | BGLF5 | 69.6 | ORF37 | 36.9 | Alk. exonuclease |
| ORF29 | BBLF1 | 38.7 | ORF38 | 16.4 | |
| ORF30 | BBRF3 | 55.6 | ORF39 | 40.5 | Glycoprotein M |
| ORF31 | BBLF2 | 20.3 | ORF40 | 13.6 | Helicase complex |
| ORF32 | BBLF3 | 22.9 | ORF41 | 14.4 | Helicase complex |
| ORF33 | BBRF2 | 55.8 | ORF42 | 27.7 | |
| ORF34 | BBRF1 | 70.6 | ORF43 | 46.6 | Capsid protein |
| ORF35 | BBLF4 | 65.3 | ORF44 | 47.8 | Helicase complex |
| ORF36 | BKRF4 | 27.7 | ORF45 | 15.2 | |
| ORF37 | BKRF3 | 73.7 | ORF46 | 46.7 | Uracil DNA glyc. |
| ORF38 | BKRF2 | 50.4 | ORF47 | 18.1 | Glycoprotein L |
| ORF39 | EBNA-1 | 36.0 | Episomal maint. | ||
| ORF40 | BRRF2 | 22.4 | ORF48 | 14.2 | |
| ORF41 | BRRF1 | 46.7 | ORF49 | 16.2 | |
| ORF42 | BRLF1 | 39.0 | ORF50 | 13.8 | Transactivator |
| ORF43 | BZLF1 | 29.0 | K8 | 13.9 | Transactivator |
| ORF44 | BZLF2 | 33.6 | |||
| EBNA3A | Nuclear protein | ||||
| EBNA3B | Nuclear protein | ||||
| EBNA3C | Nuclear protein | ||||
| C3 | |||||
| ORF45 | gp350 | 22.0 | Glycoprotein | ||
| K8.1 | |||||
| ORF46 | BLRF2 | 40.4 | ORF52 | 22.1 | |
| ORF47 | BLRF1 | 44.1 | ORF53 | 34.6 | |
| ORF48 | BLLF3 | 54.3 | ORF54 | 26.8 | dUTPase |
| ORF49 | BSRF1 | 61.5 | ORF55 | 40.0 | |
| ORF50 | BSLF1 | 46.9 | ORF56 | 27.1 | DNA replication |
| ORF51 | BMLF1 | 38.8 | ORF57 | 18.9 | Transactivator |
| K9 | |||||
| K10 | |||||
| K11 | |||||
| ORF52 | BMRF2 | 46.2 | ORF58 | 21.8 | |
| ORF53 | BMRF1 | 40.4 | ORF59 | 18.2 | DNA replication |
| ORF54 | BaRF1 | 73.5 | ORF60 | 55.4 | Ribonucleotide red. |
| ORF55 | BORF2 | 55.5 | ORF61 | 38.8 | Ribonucleotide red. |
| ORF56 | BORF1 | 46.8 | ORF62 | 29.9 | DNA maturation |
| ORF57 | BOLF1 | 37.5 | ORF63 | 18.4 | Tegument protein |