Figure 4.

The second-order rate constants for the reaction of extracellularly applied MTSEA with mutant ACh receptors in different states. (A) Second-order rate constants for receptors in the desensitized state (shaded squares; n = 3–7; this work) and in the resting (●) and open (○) states (from ref. 61). (B) The log of the quotient of the rate constant, k_D, in the desensitized state divided by the rate constant, k_R, in the resting state, for each mutant. (C) The log of the quotient of the rate constant, k_D, in the desensitized state divided by the rate constant, k_O, in the open state, for each mutant.