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The effect of the intracellular application of MTSEA to αE241C in the desensitized state. The current evoked by ACh for 10 s was recorded, and the application of ACh continued, with the addition of 5 μM proadifen, for 25 min. The cell was washed for 5 min, and ACh was applied again for 10 s. The voltage clamp was turned off 1 min after the initial application of ACh and turned on again 1 min before the second application of ACh. Traces are shown for wild type (A) and αE241C (B).
