Table 3.

Pharmacokinetic Differences Between Two Dose Schedules

	First Peak (μg/mL)*		First Trough (μg/mL) †		Subsequent Peaks (μg/mL)*		Subsequent Troughs (μg/mL) †
Cohort	Mean	SD	Mean	SD	Mean	SD	Mean	SD
3 → 3 mg/kg‡	72	33	12	7	99	41	17	10
3 → 1 mg/kg§	81	14	15	5	43	10	7	3

Abbreviation: SD, standard deviation.

^*Peaks drawn 2.5 hours after completion of infusion.

^†Troughs drawn immediately before dose (3 weeks after previous dose).

^‡Cohort 1.

^§Cohort 2.