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. Author manuscript; available in PMC: 2006 Jun 5.
Published in final edited form as: Am J Transplant. 2005 Sep;5(9):2094–2103. doi: 10.1111/j.1600-6143.2005.00995.x

Figure 7.

Figure 7

Model: Role of NK cells post-transplantation. Non-specific surgical stress and ischemia/reperfusion (I/R) injury stimulate the liver allograft to produce chemokines such as CCL2, CXCL10 and CCL3 by 6 h post-transplant. These chemokines attract recipient-derived NK cells to the liver allograft, and these graft infiltrating NK cells produce IFN-γ which can augment the later expression of chemokines including CXCL10 and CX3CL1 that promotes further infiltration of NK cells and T cells to the allograft. Finally, these cells produce cytokines including IFN-γ and mediate effector functions.