Table 3.
Distribution of the ERCC6 (rs3793784) and CFH (rs380390) SNP types and the combined effect on the disease risk
| ERCC6–C6530>G | CFH rs380390 |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Control (n = 268) |
Case (n = 460) |
OR (CI) |
|||||||
| GG | GC | CC | GG | GC | CC | GG | GC | CC | |
| CC | 45 (16.8%) | 53 (19.8%) | 16 (6.0%) | 33 (7.2%) | 66 (14.4%) | 50 (10.9%) | Reference | 1.65 (0.90–3.03) | 4.29* (2.02–9.09) |
| CG | 43 (16.0%) | 56 (20.9%) | 20 (7.5%) | 42 (9.1%) | 94 (20.4%) | 102 (22.2%) | 1.24 (0.65–2.38) | 2.17 (1.20–3.90) | 7.70* (3.86–15.34) |
| GG | 16 (6.0%) | 17 (6.3%) | 2 (0.8%) | 8 (1.7%) | 31 (6.7%) | 34 (7.4%) | 0.62 (0.23–1.69) | 2.64 (1.22–5.75) | 23.05** (5.07–104.78) |
CI, 95% confidence interval. Reference, cell was taken as the baseline for the indicated statistical calculation. ∗, P < 0.0001, using CC/GG as the reference. ∗∗, P < 0.0001, using CC/GG as reference or P < 0.05, using CC/CC (two-tailed) or CG/CC (one-tailed) as the references.