. Author manuscript; available in PMC: 2006 Jul 1.

Published in final edited form as: J Toxicol Environ Health A. 2006 Jul;69(13):1285–1309. doi: 10.1080/15287390500360133

Table 7. Distribution of CH, TCA, and TCOH in blood.

Male and female F344 rats (175–225 g body weight) were exposed to one of three doses of TRI (2, 5, 15 mmol/kg body weight in 1 ml corn oil) by oral gavage. Animals were kept in metabolic cages for up to 48 hr. Due to the nature of the tissue or fluid sampling, each time point was represented by a separate animal. Results are pmol/ml blood and are means ± SE of measurements from 3 animals for each data point. CH, TCA, and TCOH concentrations in blood were measured by GC with electron capture detection. The limits of detection were 0.3, 9, and 0.3 pmol/ml blood, respectively.

	2 mmol TRI/kg		5 mmol TRI/kg		15 mmol TRI/kg
	Male	Female	Male	Female	Male	Female
CH
2 hr	< 0.3^a	< 0.3^a	< 0.3^a	< 0.3^a	0.34 ± 0.05^a	< 0.3^a
4 hr	< 0.3^a	< 0.3^a	0.42 ± 0.13^a	< 0.3^a	0.32 ± 0.06^a	< 0.3^a
8 hr	< 0.3^a	< 0.3^a	0.70 ± 0.01^b	< 0.3^a	< 0.3^a	< 0.3^a
24 hr	< 0.3^a	< 0.3^a	0.58 ± 0.15^b	< 0.3^a	< 0.3^a	< 0.3^a
48 hr	< 0.3^a	< 0.3^a	0.69 ± 0.06^b	< 0.3^a	< 0.3^a	< 0.3^a
TCA
2 hr	< 9^a	18.2 ± 2.2^b	< 9^a	< 9^a	< 9^a	< 9^a
4 hr	< 9^a	15.8 ± 0.7^b	< 9^a	< 9^a	< 9^a	< 9^a
8 hr	< 9^a	17.1 ± 2.6^b	< 9^a	< 9^a	< 9^a	< 9^a
24 hr	< 9^a	< 9^a	< 9^a	12.4 ± 4.2^a,,cb	< 9^a	< 9^a
48 hr	10.3 ± 2.5^a	< 9^a	< 9^a	9.67 ± 2.38^a,c	< 9^a	< 9^a
TCOH
2 hr	< 0.3^a	< 0.3^a	< 0.3^a	< 0.3^a	< 0.3^a	< 0.3^a
4 hr	< 0.3^a	< 0.3^a	< 0.3^a	< 0.3^a	< 0.3^a	< 0.3^a
8 hr	< 0.3^a	< 0.3^a	< 0.3^a	< 0.3^a	< 0.3^a	< 0.3^a
24 hr	< 0.3^a	< 0.3^a	< 0.3^a	< 0.3^a	< 0.3^a	< 0.3^a
48 hr	< 0.3^a	< 0.3^a	< 0.3^a	< 0.3^a	< 0.3^a	< 0.3^a

Values for a given metabolite with different superscript letters are significantly different (P < 0.05) from one another.