Table 4.

Improvement of Power (%) by Including Flanking Markers^[Note]

	Dominant		Additive		Recessive
Design, pD=pA, and r2	SNP Only	SNP and Flanking Markers	SNP Only	SNP and Flanking Markers	SNP Only	SNP and Flanking Markers
ASP:
.1:
.25	2	9	1	6	31	46
.50	5	20	1	12	87	92
.75	14	35	1	18	89	100
1.00	24	55	2	27	100	100
.3:
.25	4	6	1	3	11	14
.50	17	19	1	4	54	56
.75	47	51	1	8	91	93
1.00	77	80	2	10	100	100
One sibling per ASP:
.1:
.25	2	8	1	5	54	61
.50	7	21	2	10	98	99
.75	21	43	3	15	100	100
1.00	39	65	4	22	100	100
.3:
.25	6	8	1	4	18	21
.50	30	34	1	7	71	74
.75	68	72	3	11	97	98
1.00	93	95	4	16	100	100

Note.— Results are based on 2,000 replicates of 500 ASPs and 1,000 cases (one sibling per ASP). All models have disease prevalence of K = 5%, sibling recurrence risk ratio of λ_s=1.02. Data were simulated using 10 flanking markers, each with four equally frequent alleles and intermarker recombination fraction 0.1. For the one sibling per ASP design, both siblings have genotypes on flanking markers. Power is assessed at the 1% level.