Figure 2.

Divergence of sequenced haplotypes from the HLA-Cw6-B57 risk haplotype. Known genes and their direction of transcription are shown below the coordinate axis, and microsatellite markers are shown above. The 298-kb PSORS1 candidate region is also depicted. The weighted percentage difference of polymorphism alleles, when compared with the sequence of the HLA-Cw6-B57 haplotype, is plotted by 2.5-kb intervals for each of the remaining six distinct haplotype clusters that were sequenced. Only those polymorphisms observed among the 10 sequenced haplotypes were considered when computing percentage difference. A plot for the second risk haplotype is shown first, followed by plots for the five nonrisk haplotypes. The bottom panel plots the number of polymorphisms observed among the 10 sequenced haplotypes, for 2.5-kb intervals of the sequenced region. The Cw6-B57 haplotype was derived from two individuals, because the region telomeric of CDSN on the Cw6-B57 chromosome of the person originally selected for cloning is actually derived from a Cw7-B8 haplotype by ancestral recombination.