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. 2006 Mar 31;78(5):827–851. doi: 10.1086/503821

Figure 4.

Figure 4

Recombinant haplotypes and test regions used to map the PSORS1 locus. Key genes and their direction of transcription, along with microsatellite markers used in this study, are depicted immediately above the coordinate axis. All founder haplotypes bearing an ancestral recombination between the HLA-Cw6 and CDSN*TTC psoriasis risk alleles are shown above the axis, and those regions tested for exclusion of the PSORS1 locus are shown below the axis. Haplotypes and test regions of the unassociated (see table 12) HLA-Cw6−/CDSN*TTC+ recombinants are shown in red; those of the associated HLA-Cw6+/CDSN*TTC− recombinants are shown in blue. Line segments for the recombinant haplotypes indicate that portion of the extended HLA-Cw6+/CDSN*TTC+ risk haplotype within the 298-kb PSORS1 candidate region that is retained by the recombinant; to be conservative, the largest possible portion of the extended risk haplotype carried by HLA-Cw6+ recombinants and the smallest possible portion of the extended haplotype not carried by HLA-Cw6− recombinants are plotted. The test regions and their bounds are shown in the same order as in table 12. The numbers of founder chromosomes in the pedigree sample are shown for each recombinant haplotype, as are the numbers of qualifying recombinant founder chromosomes for each of the tests for exclusion.