Table 6.
Number of Families Informative for Association Testing[Note]
|
No. ofInformativeFamilies |
||||
| Gene or Haplotype | TDT | PDT | FBATa | No. of Typed Families |
| HLA-C (biallelic) | 492 | 530 | 544 | 677 |
| HLA-C (multiallelic) | 623 | 634 | 642 | 670 |
| CDSN | 629 | 640 | 649 | 678 |
| HLA-C (biallelic) and CDSN haplotypes | 625 | 636 | 648 | 677 |
| 36-Marker haplotypes | 576 | 584 | … | 620 |
Note.— Although typing success was uniformly high (>99%) for all markers and haplotypes of the present study, the number of informative families varies because some families were not typed for the 34 microsatellite markers, the three association tests differ in what sort of pedigrees they can use, and dyads cannot be tested for biallelic markers. The numbers shown for each association test count only those families with at least one typed and phenotypically informative unit. For the TDT, this unit is a triad or dyad; for the PDT, it is a triad, dyad, or discordant sib pair (an affected child and unaffected sibling); and, for the FBAT with the settings used, it is a triad, dyad, discordant sib pair, or a sibship with three or more affected siblings.
As indicated by the ellipses (…), the FBAT cannot be applied to the 36-marker haplotypes, because the computational demands are too great; furthermore, FBAT can test only groups of haplotypes with exact matches for all alleles, and these constitute only a small fraction of all haplotypes in the sample.