Sequence analysis of junction fragments. A, Genomic sequence encompassing breakpoints. B, Sequence of PCR-amplified junction fragments showing the chromosome 10 genomic sequence (normal text), the sequence flanking the 10p11 breakpoint (white text), the sequence flanking the 10q21 breakpoint (underlined text), and the sequence from either 10p11 or 10q21 (boxed). The genomic sequences shown have the following coordinates in NCBI 35 (November 2005): 10p: 37,148,066–37,148,108/AL390061.9; 4,483–4,525 and 10q: 59,748,173–59,748,217/AC016396.6; 120,582–120,626.