Table 1.
List of Candidate Genes and SNPs
| Biological Pathway and Gene Symbol |
Gene Name | SNP(s) |
| Infection/inflammation: | ||
| ARTS1 | Adipocyte-derived leucine aminopeptidase | rs27895, rs26618 |
| ICAM1 | Intercellular adhesion molecule 1 | rs5491 |
| IL1A | Interleukin 1-alpha | rs17561 |
| Coagulation: | ||
| F5 | Coagulation factor V | rs6030, rs6019, rs6032 |
| Metabolic: | ||
| APOB | Apolipoprotein B | rs1042031, rs1367117 |
| INSR | Insulin receptor | rs2963 |
| LRP8 | Low-density lipoprotein receptor–related protein 8 (ApoE receptor 2) | rs3737983, rs2297660, rs5174 |
| MTHFR | 5,10-Methylenetetrahydrofolate reductase | rs1801131 |
| SLC2A2 | Solute carrier family 2 | rs1800572 |
| Vascular: | ||
| ABCC8 | ATP-binding cassette, subfamily C, member 8 | rs757110 |
| ADRA1A | Alpha-1A-adrenergic receptor | rs1048101 |
| ADRA1D | Alpha-1D-adrenergic receptor | rs835879, rs1556832 |
| ADRB2 | Beta-2-adrenergic receptor, surface | rs1042714 |
| AGTR2 | Angiotensin II receptor, type 2 | rs5191 |
| APOA4 | Apolipoprotein A-IV | rs675 |
| ATP1A1 | ATPase, Na+/K+ transporting | rs1998449 |
| B3GAT1 | Beta-1,3-glucuronyltransferase 1 | rs1440483, rs1866767 |
| CACNA1C | Calcium channel, voltage dependent, L type, alpha-1C subunit | rs215976 |
| CALCA | Calcitonin/calcitonin-related polypeptide, alpha | rs5241 |
| CALCRL | Calcitonin receptor-like | rs696092, rs858745, rs858750, rs3771083, rs698576, rs698574, rs3771073 |
| DBH | Dopamine beta-hydroxylase | rs1108580, rs5324, rs4531 |
| EDN1 | Endothelin 1 | rs2070698, rs5369 |
| EDNRA | Endothelin receptor, type A | rs702757, rs3942348, rs1517135, rs908581 |
| HCARG | Hypertension-related calcium-regulated gene | rs1209879 |
| HTR2A | 5-hydroxytryptamine (serotonin) receptor 2A | rs6314, rs6308, rs6304 |
| KLK1 | Kallikrein 1, renal/pancreal/salivary | rs3212828 |
| KLKB1 | Kallikrein B, plasma (Fletcher factor) 1 | rs4253301, rs4253325 |
| KNG | Kininogen 1 | rs1656922 |
| LPL | Lipoprotein lipase | rs328 |
| NOS2A | Nitric oxide synthase 2A (inducible, hepatocyte) | rs2297518, rs3730017 |
| NPPA | Natriuretic peptide precursor A | rs5063 |
| NPR1 | Natriuretic peptide receptor A/guanylate cyclase A | rs3891075 |
| NPY2R | Neuropeptide Y receptor Y2 | rs2880415 |
| NR3C2 | Nuclear receptor subfamily 3, group C, member 2 | rs5522 |
| PPARGC1 | Peroxisome proliferator-activated receptor-gamma, coactivator 1 | rs3736265 |
| PRCP | Prolylcarboxypeptidase (angiotensinase C) | rs2298668 |
| RENBP | Renin-binding protein | rs2269371 |
| Other: | ||
| GNA11 | Guanine nucleotide–binding protein, alpha-11 | rs2238625 |
| GNAS | GNAS (guanine nucleotide–binding protein, alphastimulating) complex locus | rs7121 |
| PRKCQ | Protein kinase C, theta form | rs2236379 |
| SLC14A2 | Solute carrier family 14, member 2 | rs3745009 |