Table 2.
Characteristics of the Black Women Included in the Initial and Confirmatory Analyses[Note]
|
Genetic Association Analyses |
||
| Characteristic | Initial (n=204) |
Confirmatory (n=1,094) |
| Age (years) | 28.9 ± 7.0 | 27.9 ± 6.6 |
| Age < 20 years | 26 (12.7) | 144 (13.2) |
| Age > 35 years | 45 (22.1) | 179 (16.4) |
| Heighta (cm) | 163.4 ± 6.5 | 163.9 ± 6.9 |
| Weighta (kg) | 71.8 ± 16.5 | 70.3 ± 17.4 |
| BMIa | 26.9 ± 5.9 | 26.1 ± 6.2 |
| BMIa < 20 | 15 (7.4) | 133 (12.2) |
| BMIa > 30 | 48 (23.5) | 209 (19.1) |
| Prenatal care during 1st trimester | 137 (77) | 715 (75.3) |
| Education (high school or beyond) | 138 (68.3) | 785 (72.8) |
| Smoking during pregnancy | 27 (13.2) | 199 (18.2) |
| Alcohol use during pregnancy | 2 (1) | 52 (4.8)b |
| Drug use during pregnancy | 22 (10.8) | 129 (11.8) |
| Married | 66 (32.4) | 364 (33.3) |
| C-section delivery | 72 (35.3) | 325 (30.5) |
| Parity (1+)c | 114 (55.9) | 684 (62.5) |
| Diabetes mellitus | 4 (2) | 16 (1.5) |
| Gestational diabetes | 12 (5.9) | 48 (4.4) |
| Pregnancy-induced hypertensiond | 92 (45.1) | 46 (4.3)b |
| Chronic hypertension | 48 (23.5) | 22 (2.0)b |
| Gestational age at delivery (wk) | 36.7 ± 4.3 | 38.0 ± 3.4b |
| Delivery at <37 wk | 81 (39.7) | 267 (24.4)b |
| Infant’s birth weight (g) | 2,625 ± 957 | 2,959 ± 775b |
| Birth weight < 2,500 g | 83 (40.7) | 252 (23)b |
| Birth weight < 1,500 g | 33 (16.2) | 57 (5.2)b |
| SBWT | −.4 ± .9 | −.3 ± 1.0 |
| FGR | 34 (16.9) | 164 (15.1) |
Note.— Data for quantitative variables are given as mean ± SD. All other data are no. (%) of subjects.
a
Before pregnancy.
b
P<.05, obtained by two-tailed t test or χ2 test.
c
“1+” means at least one previous birth.
d
Also includes preeclampsia, eclampsia, and HELLP syndrome (a syndrome characterized by hemolysis, elevated liver enzyme levels, and low platelet count).