Table 5.
Results of Analyses of Association between rs2297660 and SBWT[Note]
|
CrudeAnalysis |
AdjustedAnalysisa |
|||||||
|
Group and rs2297660 Genotype |
No. of Women |
Mean (±SD) SBWT |
β | SE | P | β | SE | P |
| Screening study: | ||||||||
| CC | 130 | −.58 ± .88 | Ref | … | … | Ref | … | … |
| AC | 63 | −.08 ± .80 | .50 | .13 | .0002 | .48 | .13 | .0004 |
| AA | 11 | .16 ± 1.11 | .74 | .29 | .01 | .67 | .29 | .02 |
| Additiveb | … | −.05 ± .85 | .44 | .11 | .00004 | .41 | .11 | .0001 |
| Validation study: | ||||||||
| CC | 541 | −.26 ± .98 | Ref | … | … | Ref | … | … |
| AC | 245 | −.14 ± 1.02 | .12 | .08 | .12 | .11 | .08 | .14 |
| AA | 46 | .03 ± .99 | .29 | .15 | .06 | .26 | .15 | .08 |
| Additiveb | … | −.11 ± 1.02 | .13 | .06 | .025 | .12 | .06 | .035 |
| Pooled analysis: | ||||||||
| CC | 671 | −.32 ± .97 | Ref | … | … | Ref | … | … |
| AC | 308 | −.13 ± .98 | .19 | .07 | .004 | .19 | .07 | .005 |
| AA | 57 | .05 ± 1.00 | .37 | .14 | .006 | .35 | .13 | .01 |
| Additiveb | … | −.10 ± .99 | .19 | .05 | .0002 | .18 | .05 | .0004 |
Note.— Ref = reference.
a
Controlled for age, parity, smoking, and BMI.
b
In additive model, CC = 0, AC = 1, and AA = 2.