Table 4.
SNPs in the 112–132-Mb Region with P⩽.0019 in the Case-Control Association Analysis[Note]
| SNP (Risk Allele) | Gene | Type | MAFcases | MAFcontrols | ORhet (95% CI) | ORhom (95% CI) | P | GIST P |
| rs10490924 (T) | LOC387715 | Ala69Ser | .410 | .259 | 1.65 (1.12–2.43) | 5.73 (3.07–10.71) | 3.13×10-8 | .05 |
| A124205188G (ss51855976) (G) | LOC387715 | Intronic | .412 | .257 | 1.70 (1.14–2.53) | 6.04 (3.22–11.33) | 1.34×10-8 | .05 |
| rs3750848 (G) | LOC387715 | Intronic | .412 | .257 | 1.66 (1.12–2.47) | 5.93 (3.16–11.14) | 2.38×10-8 | .05 |
| rs3750846 (G) | LOC387715 | Intronic | .409 | .264 | 1.52 (1.02–2.24) | 5.54 (2.96–10.38) | 1.44×10-7 | .05 |
| rs11248321 (A) | CUZD1 | Intronic | .558 | .490 | 1.40 (.89–2.22) | 2.37 (1.42–3.96) | .0009 | .41 |
| rs1891110 (G) | CUZD1/FAM24B | 5′ UTR (CUZD1); Leu2Pro (FAM24B) | .568 | .489 | 1.55 (.90–2.68) | 3.24 (1.73–6.08) | .0002 | .51 |
| rs2293435 (G) | FAM24A | 5′ UTR | .537 | .466 | 1.51 (.94–2.41) | 2.65 (1.53–4.61) | .0005 | .26 |
Note.— ORs were adjusted for age and sex and estimated separately for heterozygous (ORhet) and homozygous (ORhom) carriers of the minor allele. P values are from additive coding of SNP covariate, as described in the text. Significant P values for GIST are in bold italics.