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G451E p55 only partially protects p140 against inactivation by NEM. DNA polymerase activity was measured as described in the “Subjects and Methods” section, except that 2-mercaptoethanol was excluded. Reactions contained 75 mM NaCl, 8.0 ng (58 fmol) p140—either alone (squares) or in the presence of 6.3 ng (116 fmol) WT p55 (triangles) or G451E p55 (circles)—and the indicated amounts of NEM. Values are the average of at least two independent measurements.
