Table 6.
DTR Analysis in EAs and AAs[Note]
| Population and Variable | f | P | β |
| EAs: | |||
| European ancestry | … | .0678 | − |
| Male | … | 1.7 × 10−7 | + |
| Age | … | 8.7 × 10−29 | + |
| ADH5: | |||
| C/C | … | .0124 | + |
| ADH1A: | |||
| AGA/TGA | .203 | .0109 | + |
| AGA/TCG | .181 | .0108 | + |
| AGA/AGA | .164 | .0110 | + |
| TCG/TGA | .109 | .0108 | + |
| AGA/TGG | .088 | .0109 | + |
| TGA/TGA | .060 | .0109 | + |
| TCG/TGG | .060 | .0110 | + |
| TGA/TGG | .057 | .0108 | + |
| TCG/TCG | .055 | .0112 | + |
| ADH1B: | |||
| TCCG/CCTG | .366 | .0071 | − |
| CCTG/CCTG | .075 | .0945 | + |
| TCCA/TCCG | .058 | .0005 | − |
| ADH7: | |||
| ACGG/TCGA | .036 | .0590 | + |
| ALDH2: | |||
| ATTG/ATTG × ATTG/GCCAa | … | 4.6 × 10−9 | − |
| AAs: | |||
| Male | … | .0012 | + |
| Age | … | .0035 | + |
| ADH5: | |||
| T/T | … | .0042 | + |
| ADH5: | |||
| C/T | … | .0073 | + |
| ADH1A: | |||
| TCG/TCG | .083 | .0083 | − |
| TGA/TGA | .059 | .0451 | − |
| ADH1B: | |||
| TCCG/TCCG | .425 | .0106 | − |
| TTCG/TCCG | .270 | .0089 | − |
| TCCG/CCTG | .113 | .0100 | − |
| ADH7: | |||
| ACGG/TCGG | .216 | .0259 | + |
| ACGG/ACGG | .124 | .0425 | − |
| TCGG/TCGG | .108 | .0381 | + |
| TTGG/TCGG | .057 | .0265 | − |
| ALDH2: | |||
| GTTG/GCCA | .197 | .0306 | + |
Note.— f = diplotype frequency in cases and controls for EAs and AAs; β = regression coefficient. Only the signs (not the values) of β are shown. Positive (+) values of β reflect increased risk of the disorder when the diplotype is present; negative (−) values reflect a protective effect of the diplotype.
a
“×” indicates interaction between diplotypes.