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. Author manuscript; available in PMC: 2007 Mar 1.
Published in final edited form as: Heart Rhythm. 2006 Mar;3(3):328–335. doi: 10.1016/j.hrthm.2005.11.026

Figure 4.

Figure 4

Warming-induced QT and action potential (AP) abbreviation in arterially perfused left ventricular wedge preparation pretreated with 10 μM BaCl2. APs were recorded simultaneously from endocardial (Endo), midmyocardial (M), and epicardial (Epi) cells together with transmural ECG during a rise in perfusate temperature from 36°C to 39°C within 4 minutes (basic cycle length = 2,000 ms). Warming of the perfusate gradually and similarly abbreviates the APD of three cell types and the QT interval, resulting in reduction of Tpeak-Tend and transmural dispersion of repolarization (TDR). The tracings represent recordings of the response at 36°C, ∼37°C and 38°C, and 39°C. Note that endocardial AP failed to record at ∼38°C, so that the tracing is not shown.