Table 3. .
Age-Related Correlation in Sperm DNA–HpaII Data Set[Note]
| University Health Network Accession Number | Age Correlationa | Genome Locationb | Nearest Gene Distance (bp) |
Nearest Gene Entrez GeneID | Nearest Gene |
| UHNhscpg0007432 | −.918421653 | chr 14: 73296338-73296842 | 0 | 91748 | C14orf43 |
| UHNhscpg0004878 | −.644590225 | chr 18: 58533334-58533572 | 1,366 | 23239 | PHLPP |
| UHNhscpg0001279 | −.635499301 | chr 2: 15682160-15683012 | 0 | 1653 | DDX1 |
| UHNhscpg0010337 | −.633961562 | chr 4: 24692990-24693129 | 0 | 55203 | LGI2 |
| UHNhscpg0000523 | −.628700319 | chr 14: 89918538-89919063 | 14,066 | 801 | CALM1d |
| UHNhscpg0009687 | −.61929126 | chr 11: 71430395-71430772 | 0 | 4926 | NUMA1 |
| UHNhscpg0002060 | −.607457801 | chr 7: 117447932-117448126 | 10,775 | 56311 | ANKRD7 |
| UHNhscpg0006282 | −.603136381 | chr 14: 50203675-50203889 | 0 | 60485 | SAV1 |
| UHNhscpg0008336 | −.60134971 | chr 3: 4211475-4211590 | 0 | AY358092 | |
| UHNhscpg0002269 | −.594487623 | chr 16: 18719890-18721070 | 0 | 23204 | ARL6IP |
| UHNhscpg0006883 | −.590701745 | chr 7: 20603836-20604518 | 4,091 | 221833 | SP8 |
| UHNhscpg0003324 | −.57876246 | chr 8: 80412773-80412879 | 272,989 | 11075 | STMN2c |
| UHNhscpg0007072 | −.578612647 | chr 13: 20930559-20930802 | 0 | 253832 | FLJ25952 |
| UHNhscpg0002392 | −.577309667 | chr 12: 55758348-55759109 | 0 | 23306 | AB006624 |
| UHNhscpg0010814 | −.574206485 | chr 9: 111503780-111504547 | 0 | 548645 | GNG10 |
| UHNhscpg0002833 | −.568147866 | chr 11: 62202212-62203556 | 0 | LOC51035 | |
| UHNhscpg0007366 | −.562953631 | chr 13: 20770028-20770950 | 73,766 | FLJ25952 | |
| UHNhscpg0010640 | −.55975393 | chr 16: 81828071-81828454 | 0 | 1012 | CDH13d |
| UHNhscpg0003417 | −.55808056 | chr 8: 80412825-80412879 | 272,989 | 11075 | STMN2c |
| UHNhscpg0007351 | −.557144063 | chr 11: 133162749-133163293 | 52,433 | 219938 | SPATA19e |
| UHNhscpg0011679 | −.553844494 | chr 19: 5999835-6000028 | 0 | 5990 | RFX2e |
| UHNhscpg0011303 | −.551957348 | chr 1: 114639352-114639536 | 12,748 | 51592 | TRIM33 |
| UHNhscpg0000547 | −.551565288 | chr 9: 86126053-86126501 | 0 | 81689 | HBLD2c |
| UHNhscpg0010993 | −.550180272 | chr 1: 46478949-46480024 | 0 | 10489 | AF370430 |
| UHNhscpg0000380 | −.545084964 | chr X: 134996172-134996628 | 0 | 2273 | FHL1 |
| UHNhscpg0003556 | −.544679103 | chr X: 62745590-62745765 | 0 | 23229 | ARHGEF9c |
| UHNhscpg0002314 | −.539967585 | chr 3: 157491673-157492091 | 0 | 7881 | KCNAB1 |
| UHNhscpg0003596 | −.531788057 | chr 4: 172320378-172320459 | 934,465 | 51166 | AADAT |
| UHNhscpg0001705 | −.526787621 | chr 15: 99009623-99010314 | 2,859 | 140460 | ASB7 |
| UHNhscpg0009822 | −.526562678 | chr 1: 21855364-21855679 | 370 | AK026930 | |
| UHNhscpg0000063 | −.52421876 | chr 3: 72584222-72584350 | 5,758 | 23429 | RYBP |
| UHNhscpg0001205 | −.521667613 | chr 17: 38793230-38793666 | 8,954 | AK128207 | |
| UHNhscpg0009465 | −.518509703 | chr 5: 92982058-92982196 | 0 | 83989 | DKFZP564D172 |
| UHNhscpg0009804 | −.517599705 | chr 6: 95040381-95040442 | 854,395 | 2045 | EPHA7d |
| UHNhscpg0010111 | −.516980672 | chr 3: 45163070-45163300 | 152 | 64866 | CDCP1 |
| UHNhscpg0008321 | −.51607039 | chr 4: 32393339-32393439 | 1,572,342 | 5099 | PCDH7 |
| UHNhscpg0006596 | −.515801694 | chr 12: 6667579-6668374 | 0 | 171017 | ZNF384c |
| UHNhscpg0007045 | −.514160426 | chr 6: 39190 376-39191144 | 0 | 55776 | C6orf64 |
| UHNhscpg0003064 | −.513774745 | chr 15: 50863986-50864266 | 0 | 3175 | ONECUT1 |
| UHNhscpg0008779 | −.512617631 | chr 12: 64004487-64004759 | 0 | 253827 | LOC253827 |
| UHNhscpg0002807 | −.510358672 | chr 9: 91266376-91266791 | 859 | 4783 | NFIL3 |
| UHNhscpg0007252 | −.510001953 | chr 13: 110249836-110250880 | 68,680 | 283487 | LOC283487 |
| UHNhscpg0008979 | −.509333714 | chr 3: 97915795-97915891 | 100,433 | AY358738 | |
| UHNhscpg0002130 | −.508146229 | chr 20: 61676052-61676691 | 6,181 | 85441 | PRIC285 |
| UHNhscpg0000750 | −.506824133 | chr 11: 111449826-111451103 | 0 | 55216 | FLJ10726 |
| UHNhscpg0004733 | −.506433015 | chr 11: 77963050-77963233 | 0 | 79731 | FLJ23441 |
| UHNhscpg0007997 | −.504269038 | chr 11: 19691578-19692280 | 0 | 89797 | AJ488207 |
| UHNhscpg0011253 | −.503229452 | chr 5: 5123770-5123955 | 111,307 | 170690 | ADAMTS16 |
| UHNhscpg0001019 | −.502788473 | chr 17: 38793230-38793666 | 8,954 | AK128207 | |
| UHNhscpg0000830 | −.502263623 | chr 20: 11257478-11257784 | 588,782 | 22903 | BTBD3 |
| UHNhscpg0008888 | −.501752931 | chr 14: 46575274-46575377 | 0 | 161357 | MAMDC1c |
| UHNhscpg0005027 | −.501245356 | chr 10: 127671190-127671371 | 0 | 92565 | AY251163 |
| UHNhscpg0008252 | .50313828 | chr X: 24795508-24795821 | 1,997 | 170302 | ARXc |
| UHNhscpg0005849 | .505284858 | chr 9: 69169771-69170443 | 3,351 | 9413 | C9orf61 |
| UHNhscpg0002396 | .505405308 | chr 9: 15499859-15499960 | 0 | 11168 | PSIP1 |
| UHNhscpg0000331 | .505543224 | chr1: 114065861-114066820 | 0 | 54665 | FLJ11220 |
| UHNhscpg0004028 | .505850764 | chr 6: 109920727-109920873 | 0 | FLJ25791 | |
| UHNhscpg0003238 | .508910182 | chr 5: 72642966-72643484 | 134,358 | 2297 | FOXD1 |
| UHNhscpg0005599 | .512086932 | chr 11: 57161641-57162347 | 6,789 | 219539 | YPEL4 |
| UHNhscpg0004696 | .515663002 | chr 2: 26012699-26013466 | 0 | 55252 | ASXL2 |
| UHNhscpg0008470 | .516009324 | chr 1: 225950806-225950903 | 0 | 55746 | NUP133 |
| UHNhscpg0008340 | .51741056 | chr 4: 84313172-84313686 | 0 | 51138 | COPS4 |
| UHNhscpg0003990 | .517872516 | chr 12: 43376666-43376983 | 0 | 4753 | NELL2c |
| UHNhscpg0008557 | .518846707 | chr 10: 239933-240068 | 0 | 10771 | ZMYND11 |
| UHNhscpg0000482 | .520984085 | chr 11: 85649369-85649478 | 0 | 8726 | EEDe |
| UHNhscpg0005884 | .520992457 | chr 3: 128381578-128381626 | 13,045 | 285311 | AK097460 |
| UHNhscpg0008792 | .521754696 | chr 4: 145190267-145191203 | 5,950 | 2996 | GYPE |
| UHNhscpg0009520 | .525317277 | chr 1: 91678271-91678520 | 0 | 8317 | CDC7d |
| UHNhscpg0004355 | .526505907 | chr 6: 27464330-27464706 | 0 | 441136 | AK092633 |
| UHNhscpg0001611 | .526967248 | chr 6: 30289787-30290357 | 683 | 7726 | TRIM26 |
| UHNhscpg0004783 | .529777441 | chr 22: 15638898-15638988 | 0 | 150165 | MGC57211 |
| UHNhscpg0000025 | .532588588 | chr 10: 75370203-75371061 | 22,943 | 5328 | PLAUd |
| UHNhscpg0005928 | .535021909 | chr 1: 212554059-212554157 | 0 | 7399 | USH2A |
| UHNhscpg0001828 | .537335195 | chr 17: 17507093-17507808 | 17,703 | 10743 | RAI1 |
| UHNhscpg0005479 | .543975527 | chr 1: 215895774-215895935 | 122,221 | 127018 | LYPLAL1 |
| UHNhscpg0002565 | .545509304 | chr 6: 116998748-116999090 | 1,641 | 51389 | RWDD1 |
| UHNhscpg0008258 | .545922515 | chr 1: 114408830-114409330 | 316 | 148281 | SYT6 |
| UHNhscpg0010487 | .547254207 | chr 12: 92273678-92274142 | 234 | 11163 | NUDT4 |
| UHNhscpg0002717 | .55323384 | chr 12: 48302621-48302970 | 649 | AK123353 | |
| UHNhscpg0002673 | .553941933 | chr 15: 81825124-81825456 | 80,654 | 646 | BNC1 |
| UHNhscpg0010939 | .554017064 | chr 10: 8108807-8109019 | 23,399 | FLJ45983 | |
| UHNhscpg0001474 | .557227088 | chr 8: 53488737-53489332 | 3,881 | 9705 | ST18d |
| UHNhscpg0008206 | .559375672 | chr 14: 89155480-89155723 | 41,909 | 29018 | AF118074 |
| UHNhscpg0004409 | .560612707 | chr 12: 63850471-63850714 | 0 | 23592 | MAN1 |
| UHNhscpg0005280 | .566882321 | chr 8: 114808371-114808497 | 289,953 | 114788 | CSMD3 |
| UHNhscpg0002623 | .566952142 | chr 12: 14237814-14238207 | 171,686 | 55729 | BC063855e |
| UHNhscpg0003738 | .567376726 | chr 2: 88155376-88155675 | 10,310 | 51315 | LOC51315 |
| UHNhscpg0008444 | .570746223 | chr 10: 122728932-122729159 | 69,907 | 55717 | WDR11d |
| UHNhscpg0007259 | .575414924 | chr 1: 208139197-208139388 | 390 | 7779 | SLC30A1 |
| UHNhscpg0002607 | .582792699 | chr 2: 26481086-26481443 | 0 | 165082 | GPR113 |
| UHNhscpg0008656 | .58347414 | chr 1: 115293188-115293360 | 4,205 | 7252 | TSHB |
| UHNhscpg0002406 | .584415421 | chr 18: 48120746-48121468 | 0 | 1630 | DCCd |
| UHNhscpg0009002 | .5849705 | chr 16: 78361983-78362481 | 169,871 | 4094 | MAFd |
| UHNhscpg0007649 | .586330872 | chr 14: 80296231-80296366 | 0 | 145508 | C14orf145 |
| UHNhscpg0004597 | .587453741 | chr 22: 15638898-15638988 | 0 | MGC57211 | |
| UHNhscpg0003289 | .613126037 | chr 14: 20640986-20641802 | 4,239 | 554207 | BC031469 |
| UHNhscpg0002376 | .616193621 | chr 18: 33116047-33117280 | 0 | 56853 | BRUNOL4 |
| UHNhscpg0002145 | .617261027 | chr 1: 116672902-116673528 | 13,466 | 476 | ATP1A1 |
| UHNhscpg0000928 | .628741946 | chr 18: 32114987-32115360 | 12,305 | 55034 | MOCOS |
| UHNhscpg0008601 | .636604373 | chr 19: 40897102-40898011 | 0 | 27033 | TZFPe |
| UHNhscpg0002312 | .640025401 | chr 12: 52959901-52960341 | 457 | 3178 | HNRPA1 |
| UHNhscpg0004507 | .640711129 | chr 2: 80187757-80187860 | 0 | 1496 | CTNNA2c |
| UHNhscpg0002864 | .644197159 | chr 20: 20293918-20294056 | 2,708 | 3642 | INSM1e |
| UHNhscpg0008280 | .693689486 | chr 3: 111231569-111231663 | 692,505 | 55211 | DPPA4e |
| UHNhscpg0003180 | .698353684 | chr 2: 45078887-45079081 | 1,606 | 6496 | SIX3 |
Note.— Individuals were ordered by increasing age, and gene-specific DNA methylation dynamics were investigated using the individual ages (sperm DNA–HpaII age range 24–56 years) as a covariate.
a
Negative score = increasing methylation with respect to age. Positive score = decreasing methylation with respect to age.
b
chr = chromosome.
c
Genes related to brain/neuronal development.
d
Genes related to cancer or other disease.
e
Genes related to spermatogenesis, embryogenesis, and development.