Table 4. .
Age-Related Correlation in Sperm DNA–HHA Data Set[Note]
| University Health Network Accession Number | Age Correlationa | Genome Locationb | Nearest Gene Distance (bp) |
Nearest Gene Entrez GeneID | Nearest Gene |
| UHNhscpg0006311 | −.571461 | chr 16: 73575728-73575882 | 0 | 79726 | BC004519 |
| UHNhscpg0000757 | −.5414097 | chr 16: 3084575-3084850 | 1,713 | 84891 | ZNF206 |
| UHNhscpg0002369 | −.5080423 | chr 12: 102467385-102467934 | 15,583 | 55576 | STAB2 |
| UHNhscpg0001087 | −.5049054 | chr 2: 222992625-222992945 | 0 | 0 | FLJ32447 |
| UHNhscpg0000495 | −.4991295 | chr 2: 38215365-38216278 | 448 | 1545 | CYP1B1 |
| UHNhscpg0000562 | −.4981613 | chr 10: 21822844-21823534 | 18,875 | 387640 | FLJ45187 |
| UHNhscpg0009206 | −.4953882 | chr 2: 120996167-120996370 | 56,240 | 84931 | FLJ14816 |
| UHNhscpg0005717 | −.4945551 | chr 21: 46567171-46567396 | 1,086 | 5116 | PCNT2 |
| UHNhscpg0007805 | −.49356 | chr 2: 223623949-223624362 | 0 | 2181 | ACSL3 |
| UHNhscpg0006512 | −.4900278 | chr 12: 21985242-21985363 | 0 | 10060 | BC033804 |
| UHNhscpg0001346 | −.4890173 | chr 12: 94687435-94687958 | 0 | 0 | METAP2 |
| UHNhscpg0000367 | −.4675992 | chr 9: 123770922-123771907 | 0 | 57706 | AK024782 |
| UHNhscpg0009946 | −.4518449 | chr 17: 70661243-70661746 | 0 | 51155 | HN1 |
| UHNhscpg0007913 | −.449313 | chr 3: 44011141-44011398 | 246,983 | 375337 | AK093476 |
| UHNhscpg0002168 | −.437548 | chr 7: 13802034-13802474 | 0 | 2115 | ETV1 |
| UHNhscpg0000973 | −.4372439 | chr 18: 54013705-54014057 | 0 | 23327 | NEDD4Lc |
| UHNhscpg0001825 | −.432339 | chr 12: 94687426-94687979 | 0 | 0 | METAP2 |
| UHNhscpg0008872 | −.428427 | chr 3: 25681850-25682051 | 1,058 | 7155 | TOP2Bd |
| UHNhscpg0004998 | −.425298 | chr 18: 24676574-24676664 | 665,482 | 1000 | CDH2c |
| UHNhscpg0003543 | −.4174782 | chr 13: 93951550-93951661 | 21,626 | 1638 | DCT |
| UHNhscpg0000752 | −.4161375 | chr 19: 52308085-52308632 | 0 | 23211 | C19orf7 |
| UHNhscpg0000402 | −.4145143 | chr 10: 70330981-70331591 | 0 | 0 | AK056044 |
| UHNhscpg0000851 | −.4097783 | chr 15: 43466690-43467020 | 8,677 | 2628 | GATM |
| UHNhscpg0008103 | −.4090966 | chr 5: 78724780-78724896 | 0 | 9456 | HOMER1 |
| UHNhscpg0000874 | −.4090138 | chr 13: 45524409-45524808 | 0 | 23091 | BC019000 |
| UHNhscpg0003075 | −.4080136 | chr 12: 22379747-22379948 | 832 | 0 | SIAT8A |
| UHNhscpg0007389 | −.405673 | chr 1: 192571739-192571804 | 354,765 | 343450 | SLICK |
| UHNhscpg0001303 | −.405598 | chr 12: 50749103-50749772 | 254 | 60673 | FLJ11773 |
| UHNhscpg0008902 | −.4048977 | chr 14: 46575274-46575748 | 0 | 161357 | MAMDC1c |
| UHNhscpg0001410 | −.4042417 | chr 15: 43466690-43467020 | 8,677 | 2628 | GATM |
| UHNhscpg0001498 | −.4035585 | chr 19: 14052743-14053182 | 5,870 | 113230 | BC011002 |
| UHNhscpg0001795 | −.4022476 | chr 22: 45478515-45478970 | 97 | 25771 | C22orf4 |
| UHNhscpg0000092 | −.4017695 | chr 1: 243700095-243700378 | 45,036 | 317705 | VN1R5 |
| UHNhscpg0000407 | −.4016029 | chr 3: 159310225-159310601 | 0 | 51319 | MGC12197 |
| UHNhscpg0001152 | −.401599 | chr 4: 85773951-85774343 | 0 | 4825 | NKX6-1 |
| UHNhscpg0011244 | .400513 | chr 1: 233050707-233050741 | 0 | 55127 | AK098212 |
| UHNhscpg0008036 | .4027472 | chr 22: 22430339-22430668 | 0 | 150248 | FLJ36561 |
| UHNhscpg0009859 | .4084672 | chr 20: 38753133-38753612 | 1,843 | 9935 | MAFBd |
| UHNhscpg0011733 | .4095515 | chr 5: 78381324-78381406 | 0 | 29958 | DMGDH |
| UHNhscpg0010258 | .4143755 | chr 1: 10393997-10394274 | 0 | 5226 | PGD |
| UHNhscpg0005083 | .4183838 | chr 6: 122167296-122167347 | 354,726 | 2697 | GJA1 |
| UHNhscpg0008843 | .422049 | chr 3: 54282033-54282522 | 0 | 55799 | AF516696 |
| UHNhscpg0003506 | .4240404 | chr 2: 36496443-36496693 | 0 | 0 | CRIM1c |
| UHNhscpg0005633 | .4240989 | chr 18: 30341908-30341962 | 85,357 | 1837 | DTNAc |
| UHNhscpg0005683 | .4247309 | chr 4: 84391329-84391815 | 0 | 51316 | PLAC8 |
| UHNhscpg0010991 | .4284163 | chr 12: 78167517-78167778 | 0 | 6857 | SYT1c |
| UHNhscpg0010414 | .428641 | chr 14: 69723455-69723658 | 0 | 6547 | SLC8A3 |
| UHNhscpg0011471 | .4289618 | chr 19: 63431698-63431877 | 765 | 27300 | ZNF544 |
| UHNhscpg0011163 | .4336394 | chr 19: 58188067-58188175 | 0 | 90338 | ZNF160 |
| UHNhscpg0003691 | .4439328 | chr 8: 116422851-116423033 | 66,866 | 7227 | TRPS1 |
| UHNhscpg0011833 | .4440889 | chr 13: 99427912-99428530 | 3,789 | 0 | ZIC2c |
| UHNhscpg0005658 | .4461968 | chr 7: 4636276-4636727 | 0 | 55698 | FLJ10324 |
| UHNhscpg0003824 | .4462915 | chr 2: 107673648-107673883 | 238,538 | 285190 | BX537861 |
| UHNhscpg0006149 | .4473537 | chr 1: 193309526-193310390 | 370 | 343450 | SLICK |
| UHNhscpg0005850 | .4475083 | chr 11: 959952-960191 | 0 | 161 | AP2A2 |
| UHNhscpg0009680 | .4498291 | chr 14: 38935426-38935732 | 978 | 254170 | FBXO33 |
| UHNhscpg0009704 | .4509138 | chr 19: 45765931-45766515 | 0 | 57731 | SPTBN4 |
| UHNhscpg0007755 | .4520231 | chr 15: 76517964-76518338 | 0 | 0 | IREB2 |
| UHNhscpg0008364 | .4540589 | chr 3: 172679809-172679986 | 18,989 | 23043 | AB011123 |
| UHNhscpg0008495 | .4544119 | chr 21: 36354670-36354909 | 10 | 54093 | C21orf18 |
| UHNhscpg0006360 | .4566517 | chr 10: 102972869-102973961 | 2,762 | 10660 | LBX1e |
| UHNhscpg0005626 | .4603208 | chr 1: 43493737-43494422 | 0 | 991 | CDC20 |
| UHNhscpg0011755 | .4645775 | chr 11: 18684679-18684913 | 0 | 0 | FLJ37794 |
| UHNhscpg0009584 | .4827054 | chr 14: 38935426-38935732 | 978 | 254170 | FBXO33 |
| UHNhscpg0010541 | .4897825 | chr 20: 1875274-1875325 | 6,734 | 140885 | PTPNS1c |
| UHNhscpg0007861 | .4988212 | chr 19: 8563202-8563420 | 0 | 81794 | ADAMTS10d |
| UHNhscpg0010637 | .5227931 | chr 20: 1875274-1875325 | 6,734 | 140885 | PTPNS1c |
| UHNhscpg0005162 | .5267622 | chr 4: 123228934-123229348 | 16,718 | 0 | TRPC3 |
| UHNhscpg0011884 | .5376706 | chr 8: 39748508-39748595 | 0 | 2515 | ADAM2e |
| UHNhscpg0005387 | .5521166 | chr 19: 19634927-19635609 | 0 | 57130 | ATP13A |
Note.— Individuals were ordered by increasing age, and gene-specific DNA methylation dynamics were investigated using the individual ages (sperm DNA–HHA age range 22–35 years) as a covariate.
a
Negative score = increasing methylation with respect to age. Positive score = decreasing methylation with respect to age.
b
chr = chromsome.
c
Genes related to brain/neuronal development.
d
Genes related to cancer or other disease.
e
Genes related to spermatogenesis, embryogenesis, and development.