Table 1. .

Association Analyses of rs498055 in Two Independent Family Samples^[Note]

	FBAT Statistic Result
Sample^a	G Allele Frequency	No. of Informative Families	Z Score^b	P
All Families:
NIMH	.519	123	−1.096	.27
CAG	.504	84	−.194	.85
Combined	.514	207	−1.001	.32
Families with late-onset disease:
NIMH	.537	81	−1.541	.12
CAG	.531	66	−.808	.42
Combined	.535	147	−1.703	.09
APOE ɛ4-positive families:
NIMH	.494	107	−1.488	.14
CAG	.515	31	−1.380	.17
Combined	.499	138	−1.929	.06

Note.— Association tests were performed using FBAT (v1.5.5) with an additive transmission model, the empirical variance function, and an equal-weight offset correction for affected and unaffected individuals (see the FBAT Web site for more details).

Families were classified as “late onset” when all sampled affected individuals had age at onset of >65 years and were classified as “APOE ɛ4 positive” when at least one affected individual per family carried the ɛ4 allele. The smaller strata of remaining families (i.e., those displaying an earlier age at onset or those in which none of the affected individuals carried an ɛ4 allele) also failed to show evidence of significant association (data not shown).

For the G allele of rs498055, which was reported as the putative risk allele by Grupe et al.¹ (positive values indicate overtransmission to affected individuals). Note that the direction of transmission is consistent for both family samples analyzed here and is opposite to that seen in the previous publication.¹