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. 2005 Jun 9;567(Pt 1):143–157. doi: 10.1113/jphysiol.2005.090035

Figure 7. Inhibition of IP3 receptor signalling or SR Ca2+ release inhibits PE-induced stimulation of NOI.

Figure 7

A and B, compared to control (cntrl) PE (10 μm)-induced stimulation of NOi release was blocked by 2 μm 2-APB (A) and markedly inhibited by 2 h incubation in 10 μm xestospongin C (+ Xesto C) (B). C, prior exposure to 10 μm ryanodine blocked PE-induced stimulation of NOi release. D, summary of the effects of 2-APB, xestospongin C, and ryanodine compared to control (filled bar) effects of PE to increase NOi. The numbers in parentheses indicate that number of cells tested in each experiment. *P < 0.01; †P < 0.05.