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. 2005 Jun 9;567(Pt 1):177–190. doi: 10.1113/jphysiol.2005.090639

Figure 6. Sex-dependent effects of reduced glutathione (GSH) on outward currents in ventricular cells from STZ-induced diabetic rats.

Figure 6

A, current traces obtained from two cells obtained from males, in response to 500-ms voltage steps from −80 mV to potentials ranging from −10 to +50 mV, in the absence (left) or following 5.5 h in the presence of 1 mm GSH (right). Below are the current–voltage relationships, with mean (±s.e.m.) current densities plotted against membrane potentials in the absence (•) or following 5–8 h the presence of in GSH (▪). GSH significantly augments both Ipeak (left) and Isus (right). B, Current–voltage relationships obtained in cells from diabetic females (current traces omitted for clarity). No effects of GSH on Ipeak or Isus were observed in these cells. C, in contrast, the effects of GSH are restored in diabetic females that had been ovariectomized. *P < 0.05; **P < 0.005.