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. 2005 Jun 9;567(Pt 1):177–190. doi: 10.1113/jphysiol.2005.090639

Figure 8. The effects of apocynin are blunted by angiotensin in cells from male diabetic rats.

Figure 8

A, mean current densities (at +50 mV) are shown in the absence of drugs (−) apo., after 5–8 h incubation with 300 μm apocynin (+) apo., and in the presence of apocynin and 300 nm ANG II, added 1 h before apocynin (apo. + ANGII). ANG II significantly (P < 0.05) reversed current augmentation elicited by apocynin. Ipeak is shown on the left and Isus on the right. B, mean DHE fluorescence intensity mirrored these changes. Apocynin reduces DHE fluorescence in cells from diabetic rats (100%), but this effect is blunted by 300 nm ANG II.