Figure 4. Inhibition of I_Na by mibefradil.

A, every 5 s, DVR pericytes were depolarized from a holding potential of −90 mV to −10 mV for 50 ms. During the pulses, increasing concentrations of mibefradil were introduced into the extracellular buffer. Superimposed traces show an example of the inhibition of I_Na as mibefradil was increased from 0 μm to 0.1, 1 and 10 μm. B, summary of peak inward I_Na versus mibefradil concentration. *P < 0.05 versus 0 μm mibefradil, n = 4, 6 and 10 cells at 0.1, 1.0 and 10 μm, respectively.