Figure 1. Role of NO and prostanoids in the regulation of systemic vascular tone.

Effect of cyclo-oxygenase inhibition (indometacin (Indo), left panels) and NO synthase inhibition (NLA, right panels) and combined inhibition of cyclo-oxygenase and NO synthase (Indo + NLA, right panels) on the relation between body O₂ consumption and systemic vascular resistance (upper panels) and the mixed venous O₂ saturation (lower panels). Data are mean ±s.e.m. Dot inside symbol denotes P < 0.05 versus corresponding value at rest, *P < 0.05 versus control; †P < 0.05 versus NLA.