Figure 2. Role of NO and prostanoids in the regulation of pulmonary vascular tone.

Effect of cyclo-oxygenase inhibition (Indo, left panels) and NO synthase inhibition (NLA, right panels) and combined inhibition of cyclo-oxygenase and NO synthase (Indo + NLA, right panels) on the relation between body O₂ consumption and pulmonary vascular resistance. Indometacin had no effect on pulmonary vascular resistance either under control conditions or in the presence of NLA. Data are mean ±s.e.m. Dot inside symbol denotes P < 0.05 versus rest; *P < 0.05 versus control.