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. 2005 Aug 4;568(Pt 2):629–638. doi: 10.1113/jphysiol.2005.094227

Figure 3. Interaction between NO, prostanoids and endothelin in the regulation of systemic vascular tone.

Figure 3

From left to right: effect of endothelin receptor blockade (tezosentan (Tezo)), cyclo-oxygenase inhibition and endothelin receptor blockade (Indo + Tezo), NO synthase inhibition and endo-thelin receptor blockade (NLA + Tezo) and combined inhibition of cyclo-oxygenase and NO synthase and endothelin receptor blockade (NLA + Indo + Tezo) on the relation between body O2 consumption and systemic vascular resistance (upper panels) and the mixed venous O2 saturation (lower panels). Data are mean ±s.e.m.*P < 0.05 effect of Tezo versus corresponding control; †P < 0.05 effect of Tezo in presence of Indo, NLA or NLA + Indo versus Tezo alone; ‡P < 0.05 effect of Tezo in presence of NLA or NLA + Indo versus effect of Tezo in the presence of Indo; ¶P < 0.05 effect of Tezo in presence of NLA + Indo versus effect of Tezo in the presence of NLA.