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. 2005 Aug 4;568(Pt 2):629–638. doi: 10.1113/jphysiol.2005.094227

Figure 4. Interaction between NO, prostanoids and endothelin in the regulation of pulmonary vascular tone.

Figure 4

From left to right: effect of endothelin receptor blockade (tezosentan (Tezo)), cyclo-oxygenase inhibition and endo-thelin receptor blockade (Indo + Tezo), NO synthase inhibition and endothelin receptor blockade (NLA + Tezo) and combined inhibition of cyclo-oxygenase and NO synthase and endothelin receptor blockade (NLA + Indo + Tezo) on the relation between body O2 consumption and pulmonary vascular resistance. Indometacin had no effect on the response of pulmonary vascular resistance to tezosentan either under control conditions or in the presence of NLA. Data are mean ±s.e.m.*P < 0.05 effect of Tezo versus corresponding control; †P < 0.05 effect of Tezo in presence of Indo, NLA or NLA + Indo versus Tezo alone; ‡P < 0.05 effect of Tezo in presence of NLA or NLA + Indo versus effect of Tezo in the presence of Indo.