. 2005 Aug 4;568(Pt 2):629–638. doi: 10.1113/jphysiol.2005.094227

Table 1.

Haemodynamics of swine at rest and during exercise

	Rest		Exercise level (km h⁻¹)

Treatment	Lying	Standing	1	2	3	4	5
HR (bpm)
Control	126 ± 5	147 ± 5^*	169 ± 6^*	186 ± 5^*	202 ± 6^*	232 ± 8^*	265 ± 5^*
Tezo	150 ± 5^‡	163 ± 5^*^‡	184 ± 6^*	198 ± 8^*	214 ± 7^*^‡	243 ± 9^*^‡	267 ± 6^*
Indo	86 ± 7^†	97 ± 5^*^†	121 ± 6^*^†	134 ± 6^*^†	150 ± 6^*^†	174 ± 6^*^†	204 ± 7^*^†
Indo + Tezo	97 ± 7^†^‡	112 ± 5^*^†^‡	128 ± 6^*^†	141 ± 6^*^†	157 ± 7^*^†	178 ± 8^*^†	212 ± 9^*^†
NLA	97 ± 5^†	115 ± 3^*^†	129 ± 6^*^†	139 ± 6^*^†	156 ± 6^*^†	190 ± 9^*^†	225 ± 9^*^†
NLA + Tezo	112 ± 6^†	136 ± 7^*^†^‡	146 ± 8^*^†^‡	154 ± 7^*^†^‡	176 ± 8^*^†^‡	201 ± 8^*^†^‡	234 ± 10^*^†
NLA + Indo	82 ± 7^†	93 ± 8^*^†	110 ± 8^*^†	122 ± 12^*^†	134 ± 10^*^†	164 ± 13^*^†	193 ± 12^*^†
NLA + Indo + Tezo	100 ± 10^†	116 ± 8^*^†^‡	127 ± 6^*^†^‡	138 ± 7^*^†	153 ± 13^*^†^‡	171 ± 11^*^†	194 ± 10^*^†
CO (l min⁻¹)
Control	3.6 ± 0.2	4.5 ± 0.2^*	5.3 ± 0.3^*	5.9 ± 0.3^*	6.4 ± 0.3^*	7.1 ± 0.3^*	7.8 ± 0.4^*
Tezo	4.0 ± 0.2^‡	4.7 ± 0.3^*	5.5 ± 0.3^*	6.1 ± 0.4^*	6.8 ± 0.4^*^‡	7.6 ± 0.4^*^‡	8.2 ± 0.4^*
Indo	2.6 ± 0.3^†	3.2 ± 0.3^*^†	4.1 ± 0.3^*^†	4.5 ± 0.3^*^†	5.1 ± 0.3^*^†	6.2 ± 0.3^*^†	7.2 ± 0.3^*
Indo + Tezo	3.0 ± 0.2^†	3.8 ± 0.3^*^†^‡	4.4 ± 0.3^*^†	5.2 ± 0.4^*^‡	5.6 ± 0.4^*^‡	6.4 ± 0.4^*	7.5 ± 0.5^*
NLA	3.1 ± 0.4^†	3.8 ± 0.2^*^†	4.5 ± 0.3^*^†	4.9 ± 0.3^*^†	5.4 ± 0.3^*^†	6.4 ± 0.4^*^†	7.1 ± 0.4^*^†
NLA + Tezo	3.8 ± 0.4^‡	4.7 ± 0.4^*^‡	5.2 ± 0.4^*^†^‡	5.6 ± 0.4^*^†^‡	6.4 ± 0.3^*^†^‡	7.3 ± 0.4^*^†^‡	8.2 ± 0.5^*^‡
NLA + Indo	2.0 ± 0.3^†	2.3 ± 0.3^†	3.1 ± 0.3^*^†	3.7 ± 0.4^*^†	4.1 ± 0.3^*^†	5.1 ± 0.5^*^†	6.0 ± 0.3^*
NLA + Indo + Tezo	3.1 ± 0.3	3.8 ± 0.4^‡	4.2 ± 0.3^*^‡	4.9 ± 0.3^*	5.2 ± 0.3^*^‡	5.8 ± 0.3^*	6.6 ± 0.4^*^‡
MAP (mmHg)
Control	97 ± 3	90 ± 3^*	89 ± 2^*	90 ± 3^*	89 ± 2^*	92 ± 2^*	93 ± 2
Tezo	91 ± 2	82 ± 3^*^‡	81 ± 2^*^‡	79 ± 2^*^‡	82 ± 2^*^‡	83 ± 2^*^‡	85 ± 2^*^‡
Indo	124 ± 7^†	120 ± 7^†	107 ± 6^*^†	106 ± 6^*^†	107 ± 5^*^†	104 ± 5^*	101 ± 4^*
Indo + Tezo	111 ± 3^†	93 ± 3^*^†^‡	89 ± 2^*^†^‡	89 ± 3^*^†^‡	89 ± 3^*^‡	88 ± 3^*^‡	89 ± 3^*^‡
NLA	124 ± 3^†	118 ± 3^†	115 ± 3^†	115 ± 2^*^†	118 ± 2^†	119 ± 2^†	119 ± 3^†
NLA + Tezo	112 ± 5^†	103 ± 3^†^‡	99 ± 4^*^†^‡	99 ± 3^*^†^‡	100 ± 3^*^†^‡	98 ± 3^*^†^‡	98 ± 2^*^†^‡
NLA + Indo	166 ± 8^†	163 ± 8^†	151 ± 6^*^†	145 ± 5^†	140 ± 3^*^†	134 ± 4^*^†	128 ± 5^*^†
NLA + Indo + Tezo	128 ± 5^†^‡	118 ± 7^*^†^‡	113 ± 6^*^†^‡	114 ± 6^*^†^‡	115 ± 7^*^†^‡	113 ± 6^*^†^‡	113 ± 8^*^†^‡
MPAP (mmHg)
Control	15 ± 1	15 ± 2	19 ± 1^*	21 ± 1^*	23 ± 1^*	28 ± 2^*	33 ± 1^*
Tezo	16 ± 1	13 ± 2	17 ± 2	18 ± 2	21 ± 2^*^‡	25 ± 2^*^‡	28 ± 2^*^‡
Indo	19 ± 1	18 ± 2	18 ± 2	20 ± 2	22 ± 2^*	26 ± 2^*	29 ± 2^*
Indo + Tezo	17 ± 2	14 ± 2^*^‡	15 ± 2	17 ± 2	20 ± 2	23 ± 2^*	26 ± 2^*
NLA	25 ± 2^†	22 ± 2	25 ± 2^†	27 ± 2^†	31 ± 2^*^†	38 ± 2^*^†	44 ± 1^*^†
NLA + Tezo	18 ± 2	19 ± 2	18 ± 2^†^‡	21 ± 1^‡	25 ± 2^*^†^‡	29 ± 3^*^‡	33 ± 3^*^‡
NLA + Indo	24 ± 2^†	26 ± 3^†	27 ± 3	29 ± 3	31 ± 3^*	35 ± 2^*^†	37 ± 3^*
NLA + Indo + Tezo	19 ± 2	17 ± 3	20 ± 2	23 ± 3	25 ± 3	28 ± 4^*^‡	31 ± 3^*^‡
MLAP (mmHg)
Control	4 ± 1	2 ± 2	3 ± 1	4 ± 1	6 ± 1	7 ± 1^*	11 ± 1^*
Tezo	4 ± 1	0 ± 1^*	3 ± 1	3 ± 1	6 ± 1	8 ± 1^*	10 ± 1^*
Indo	10 ± 2^†	7 ± 2	3 ± 2^*	6 ± 1^*	6 ± 1^*	7 ± 2	8 ± 2
Indo + Tezo	8 ± 1	2 ± 1^*^‡	3 ± 2^*	4 ± 1^*	6 ± 1^*	7 ± 1	8 ± 2
NLA	11 ± 1^†	5 ± 2^*	7 ± 1^*	8 ± 1^*	9 ± 1^*	10 ± 1^*	12 ± 1^*
NLA + Tezo	3 ± 3	5 ± 1^*	4 ± 2^*	7 ± 1^*	9 ± 1^*	11 ± 2^*	13 ± 2^*
NLA + Indo	16 ± 3^†	15 ± 4^†	13 ± 4	14 ± 3^†	14 ± 3^†	12 ± 3	10 ± 3
NLA + Indo + Tezo	7 ± 3^‡	4 ± 4	5 ± 2	8 ± 2	9 ± 2	11 ± 3	12 ± 2

HR: heart rate, CO: cardiac output, MAP: mean arterial pressure, MPAP: mean pulmonary arterial pressure, MLAP: mean left atrial pressure. Tezo: tezosentan, Indo: indometacin, NLA: N^ω-nitro-l-arginine. Data are mean ±s.e.m.;

P < 0.05 versus rest (lying);

^†

P < 0.05 versus corresponding control

^‡

P < 0.05 effect of tezosentan.